关于举办华南理工大学“海内外优秀青年学者论坛”医学院分论坛的通知

发布时间:2017-12-25设置

广大师生:

华南理工大海内外优秀青年学者论坛医学院分论坛将于20171228日举行,该论坛旨在面向全球邀请拥有不同学术背景的青年才俊,围绕国际科学前沿、热点研究领域以及行业产业的技术问题等展开探讨和交流。通过这个平台,互相启迪、开拓视野,增强国际交流与合作,促进双方共同发展。

一、论坛时间

2017122814:30-17:30

二、地点

华南理工大学大学城校区B2-101

三、论坛议程

日期

时间

事项或议程

地点

1227

(周三)

全天

报到、入住

大学城中心酒店

1228

(周四)

下午

14:30-14:40

开幕式

主持人:李继承

学院领导致欢迎词

大学城校区

B2-101

14:40-17:30

学术报告

(每位45分钟)

主持人:李继承

题目:tRNA epigenetics in human diseases

报告人:汪肖云 博士,美国美国芝加哥大学医学院

题目:Computerized Histomorphometric Image Analysis of Oropharyngeal and Oral Cavity Squamous Cell Carcinomas

报告人:陆铖博士,美国凯斯西储大学

题目:Nanostructured Materials for Biomedical Applications

报告人:袁佩妍博士,新加坡国立大学

题目:Macromolecules for Antimicrobial Applications

报告人:丁鑫博士,新加坡生物工程与纳米技术研究所

欢迎广大师生参加!

 

 

华南理工大学医学院

20171225

 

 

附件:

1. tRNA epigenetics in human diseases(汪肖云博士)  

内容摘要:

RNA epigenetics is a new field that studying the role of RNA modifications on gene expression and subsequent cellular consequences. There are numerous types of RNA modifications on human tRNA, which is a key regulator of protein synthesis. In this report, I will talk about how tRNA regulates genetic codes to generate natural mutations during translation and how microbiome-derived tRNA modification regulates human gut diseases through codon preference in translation. Our results showed that tRNA epigenetics could modulate translation fidelity to adapt environmental changes, in addition, microbiome-derived tRNA modification can mediate translation speed and RNA metabolism to regulate cell biology. I will also talk about my PhD work studying functional genomics of liver fluke, which is an important foodborne pathogen in the South of China.

报告人简介:

汪肖云博士目前在美国芝加哥大学生物化学与分子生物学专业从事研究工作,博士后阶段主要研究非编码RNA (tRNA)和信使RNA (mRNA)在蛋白质合成中调控疾病发生的分子机制。2017年作为独立PI获得美国NIH 消化系统疾病研究所K系列青年研究员基金连续资助5年,用于研究人体肠道微生物与宿主相互作用的RNA表观遗传学分子机制。博士阶段在中山大学医学院病原生物学专业完成硕博连读学习,作为课题组骨干成员参与国家973计划和863计划研究我国重要食源性寄生虫病致病机制和预防策略。2015年因此获得国际分子寄生虫学委员会授予Odile Bain Memorial Prize国际贝恩纪念奖。研究成果以第一作者和合作作者已发表在PLOS Genetics, Genome Biology, Cell Reports, Cell, RNA Biology, Scientific Reports, Vaccine, PLoS Negl Trop Dis., Parasit Vectors等国际杂志。共发表SCI论文50多篇,其中第一作者和通讯作者15篇。发表论文总引用次数800多次,论文总影响因子超过200分。主要研究兴趣为应用高通量组学技术(基因组、转录组、蛋白质组)筛选鉴定重要病原微生物感染致病关键分子;重要人兽共患病/食源性病原体/虫媒病/肠道病原体的致病机制和预防策略;病原微生物与宿主相互作用的RNA表观遗传学分子机制研究;感染性疾病诊断检测技术和疫苗研制技术的转化开发研究。

 

2. Computerized Histomorphometric Image Analysis of Oropharyngeal and Oral Cavity Squamous Cell Carcinomas(陆铖博士)

内容摘要:

In this presentation, I will introduce the development of quantitative analytic tools which can enable identification and evaluation of sub-visual image features orhistologic biomarkers for discriminating more from less aggressive (a) oropharyngeal squamous cell and (b) oral cavity cancers. The successful validation of discoveredhistologic biomarkerscould pave the way for enabling decision support tool for informing prognosis counseling and clinical and treatment management in the context of precision medicine.

报告人简介:

陆铖,博士,副教授,2013年在加拿大艾伯塔大学获得博士学位,研究方向为医学图像分析与模式识别。2015年作为博士后研究员加入凯斯西储大学由Madabhushi教授领导的计算图像与个人诊断中心(CCPID),近5年来在《Nature Modern Pathology》《Nature Scientific Reports》《Pattern Recognition》等国际知名SCI期刊发表论文20余篇(其中第一作者论文14篇),国际会议论文6篇(EI收录4篇)并在重要国际会议USCAPISMRM上做邀请报告。

 

3. Nanostructured Materials for Biomedical Applications(袁佩妍博士)

内容摘要:

Over the past decades, nanostructured materials have attracted increasing attention in biomedical research. Owing to their superior properties (e.g. good optical properties, high loading capacity and/or versatile surface functionalization), they have been widely used in biosensor, bioimaging, drug delivery and therapy. In this presentation, I will first introduce our efforts on employing cell-penetrating peptides modified mesoporous silica nanoquenchers to achieve endocytosis-independent rapid cellular uptake and novel diagnostics/bioimaging as well as smart drug controlled released. In addition, I will discuss our recent research on novel delivery system of therapeutic protein/antibody. Both breakable silica nanoparticles and cell-penetrating peptides were utilized to achieve efficient intracellular delivery of protein/antibody under different responsive simulation. Apart from these, I will also present our studies on optical properties of different nanostructured materials and their biomedical applications in this talk.

报告人简介:

袁佩妍博士于2008在中山大学应用化学系获得学士学位, 并且于2014年在新加坡国立大学化学系获得博士学位。博士毕业至今在新加坡国立大学从事博士后研究。她一直从事纳米材料的生物医药应用方面的研究工作,主要的研究方向是靶向药物控释,荧光探针的研发,生物成像及癌细胞/细菌的检测及治疗。近年来一共发表SCI收录论文21篇,著作1篇,包括J. Am. Chem. Soc.Angew. Chem. Int. Ed. Small Nanoscale ACS Appl. Mater. Interfaces等,其中1篇一作论文被评为ESI高被引论文1篇。

 

4. Macromolecules for Antimicrobial Applications(丁鑫博士)

内容摘要:

Bacterial biofilm and multidrug resistant (MDR) bacteria responsible for most nosocomial infections are great clinical challenges. To prevent biofilm formation on medical device, antibacterial or antifouling coatings are two effective strategies, but both strategies have their limitations. In this talk, I will present several facile antibacterial and antifouling macromolecular coatings which incorporate antibacterial cations, antifouling PEG and adhesive dopamine. These coatings exhibited enhanced anti-biofilm activity. In addition, hierarchical polymer brushes with antifouling moieties were also developed to load antibiotics on surface to prolong anti-biofilm activity. To address the challenge of antibiotic resistance, potent antimicrobial polycarbonates have been previously developed in our lab. Taking advantage of their membrane lytic action mechanism, we used these polymers as adjuvant to enhance potency of conventional antibiotics. The minimal inhibitory concentration (MIC) of antibiotics against both susceptible and MDR Gram-negative bacteria was greatly reduced over ~1000 fold when the antibiotics were combined with polymer at sub-MIC level, indicating the great potential of the combination therapy for treatment of MDR bacterial infections.

报告人简介:

丁鑫博士于2008年在西安交通大学材料学院获得工学学士学位,2014年在新加坡国立大学综合科学与工程研究生院获得博士学位,博士毕业至今一直在新加坡生物工程与纳米技术研究所从事博士后研究。他主要研究方向包括用于医用植入体表面改性的高分子涂层、新型抗菌高分子和抗菌金属纳米粒子的研究。研究成果发表在Advanced MaterialsBiomaterials等生物材料领域权威期刊,并获得两项已授权的美国专利。他多次参加重要国际学术会议,并在第六届国际先进材料与纳米技术大会(AMN-6)上获得生物或化学领域最佳学生口头报告荣誉。

 


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