[Lecture] Lipases in the gut: from structure-function relationships to the treatment of obesity and pancreatic enzyme replacement therapy

2019-01-09

Title: Lipases in the gut: from structure-function relationships to the treatment of obesity and pancreatic enzyme replacement therapy
Speaker: Prof. Frédéric Carrière (National Centre for Scientific Research, France)
Venue: Dongtang Hall, Building No.13, Wushan Campus
Time: Jan 14, Monday, 10:30-11:30

Abstract:
Frédéric Carrière is Research Director at the French National Centre for Scientific Research (CNRS). He received a degree in Chemical Engineering from Marseille High School of Chemistry in 1986 and a PhD in Enzymology from Aix-MarseilleUniversity in 1992. From 2004 to 2017, he was Director of the Laboratory of Enzymology at Interfaces and Physiology of Lipolysis, a joint unit of CNRS and AixMarseilleUniversity. Since 2018, he joined the Enzymology of Supramolecular Systems’group of the Bioenergetics and Protein Engineering lab, Marseille, France. Frédéric Carrière wrote around 200 publications dealing with the structure-function relationships and physiological roles of lipases (see https://www.researchgate.net/profile/Frederic_Carriere). At the molecular level, his work aims at understanding the mechanism of action of lipases at lipid-water interfaces and monitoring their catalytic activity and specificity. These are major issues because lipases have many industrial and medical applications. He also performed several clinical studies on gastrointestinal lipolysis in collaboration with pharmaceutical industry and has established the respective contributions of gastric and pancreatic lipases to fat digestion in healthy humans. This clinical work has been used for developing lipase inhibitors for obesity treatment, new lipases for pancreatic enzyme replacement therapy, as well as in vitro digestion methods for testing dietary lipids or oral lipid-based drug delivery systems.


Announced by School of Food Science and Engineering


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