[Young Scholar's Forum] Topics on nanomedicines

2019-01-09

Time: Monday, Jan 14, 2018, 15:00-17:00
Venue: Room 101, Building B2, University Town Campus


Lecture 1: Nanomedicines for cancer treatment and immunotherapy 
Speaker: Dr. Zhang Yuan (University of Rhode Island)

Abstract:
This presentation will focus on the prevention and treatment of cancer and infectious disease using nanotechnology and bioengineering approach, and cover the following topics: chemotherapy and gene therapy, systemic delivery of immunostimulatory cytokines and antibodies, development of subunit- and gene- based synthetic vaccines, and modulation of myeloid cells to improve immunity.

Biography:
Dr.Yuan Zhang received bachelor and master degree from Peking University School of Pharmaceutical Sciences, and Ph.D. degree from the University of North Carolina at Chapel Hill, Eshelman School of Pharmacy in Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery. Dr. Zhang conducted Postdoctoral fellowship at the David H. Koch Institute for Integrative Cancer Research at MIT in the field of Bio-immuno-engineering. Dr. Zhang is currently an Assistant Professor at the University of Rhode Island, College of Pharmacy in Department of Biomedical and Pharmaceutical Sciences.


Title 2: Vapour nanobubble and its application in intracellular delivery
Speaker: Dr. Ranhua Xiong (Ghent University)

Abstract: 
Cytosolic delivery of foreign nanomaterials into living cells is an important step for cell studies. Delivering such nanomaterials into cells requires overcoming the cell membrane, which is a major biological barrier to macromolecules and nanoparticles. In this lecture, we will focus on intracellular delivery by photoporation and relevant applications. We first give a detailed review on photoporation and its main principles. Having found that VNB photoporation is the more efficient mechanism for permeabilizing the cell membrane, we make use of it to deliver of imaging contract agents into cells for improved long-term in vivo cell tracking. Next we show that VNB photoporation can be used to deliver extrinsic labels into cells for microscopic visualization of subcellular structures of living cells. Finally, we develop a fully automated VNB photoporation platform, for fast and flexible spatially resolved photoporation of selected cells with several unique applications.


Announced by the School of Biomedical Science and Engineering

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