关于举行香港中文大学魏涛教授学术报告的通知

发布时间:2022-05-16设置

报告题目:Tailored-made Polymer Coatings for Orthopaedic Applications

报 告 人:魏涛教授 香港中文大学

报告时间:202251810:0011:30

报告地点:腾讯会议ID240657646

欢迎广大师生参加。

 

 

材料科学与工程学院

2022516

 

 

报告人简介:

魏涛现为香港中文大学(CUHK)化学系教授、理学院副院长及英国皇家化学会会士(FRSC)。魏涛教授于1999年以一等荣誉毕业于CUHK化学系,于2003年在CUHK获得博士学位,研究方向为光散射和溶液中的聚合物相互作用。20032005年在德国巴斯夫(路德维希港总部)进行博士后研究,从事胶体和表面化学方面的工作。2005年在明尼苏达大学化学系进行短期博士后培训后,于2006年加入CUHK化学系担任研究助理教授,2008年任助理教授,2012年晋升副教授,2017年晋升教授。他目前的研究兴趣主要为胶体、表面化学、聚合物和软物质。

To NGAI now is Professor in the Department of chemistry, Assistant Dean (Research) of the Faculty at the Chinese University of Hong Kong (CUHK), and Fellow of the Royal Society of Chemistry (FRSC). He received his B.Sc. in chemistry at CUHK in 1999. In 2003, he obtained the Ph.D. at the same university, where he worked on light scattering and polymer interaction in solution. He moved to BASF (Ludwigshafen, Germany) in 2003 as the postdoctoral fellow for two years, working on colloids and surface chemistry. After a short postdoctoral training in the Chemistry Department at the University of Minnesota in 2005, he joined the Chemistry Department at CUHK in 2006 as a research assistant professor. He has been appointed as an assistant professor in 2008, and promoted to associate professor in 2012. In 2017, he was promoted to Professor. His current research interests center around the colloids, surface chemistry, polymers and soft matter.

 

报告简介:

在过去的几十年中,镁(Mg)及其合金作为下一代金属骨植入材料被深入研究,但它们于生理环境下的快速腐蚀大大阻碍了其进一步的临床应用。本次讲座中,魏教授将介绍其课题组近期在纯Mg基材(99.99 wt.%)表面设计制备可生物降解聚(L-乳酸)(PLLA)涂层的相关工作。通过将浸涂技术与混合非溶剂诱导相分离技术相结合(Dip-coating-mNIPS),可实现PLLA涂层表面形貌和结构的有效调控,进而调节Mg基材的腐蚀行为及生物相容性。通过使用不同组成的混合溶剂,一系列具有不同孔径和形貌的PLLA涂层被成功制备。此外,一种由PLLA和水溶性镁盐颗粒组成的有机-无机复合涂层被设计开发作为纯镁基材表面的抗腐蚀性保护层。与PLLA单一涂层相比,此复合涂层可在抑制Mg基材降解的同时实现Mg2+在初始阶段的快速释放。体外实验表明该复合涂层改性的镁基材料有利于细胞粘附和附着、细胞扩散和细胞增殖,展现出该基于PLLA的复合涂层在骨科应用中的极大潜能。

Magnesium (Mg) and its alloys have been intensively explored as the next-generation of metallic bone implants in the past decades, but their rapid corrosion rate in physiological environments is still a great hindrance for further therapeutic applications. In this talk, I will introduce our recent work in designing the biodegradable poly (L-lactic acid) (PLLA) coatings on pure Mg substrates (99.99 wt.%) with tunable surface morphologies through dip-coating in combination with mixed non-solvent induced phase separation (Dip-coating-mNIPS) method to regulate the corrosion behavior and biocompatibility. By using the mixtures of solvents, we obtained PLLA coatings with different pore sizes and morphologies. We further developed an organic-inorganic composite coating consisting of PLLA and water-soluble Mg salt particles served as a protective layer on the surface of a pure Mg substrate. Compared to the pure PLLA coating, the implementation of such composite coating could allow for quick initial release of Mg2+ and impeded degradation of the Mg substrate simultaneously. In particular, we demonstrated that the composite-coated sample favored cellular adhesion and attachment, cell spreading, and cellular proliferation. These encouraging in vitro data provide significant evidence of the potential practical value of this PLLA-based composite coating on Mg substrates for numerous orthopedic applications.

 

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